CD268/BAFF-R Rekombinanter Antikörper

CD268/BAFF-R Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

243120H8

Kat-Nr. : 98404-1-RR

Synonyme

BAFF receptor, Baffr, BAFF-R, B-cell maturation defect, B-cell-activating factor receptor

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  FC experiment of mouse splenocytes using 98404-1-RR

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD268/BAFF-R Rabbit RecAb (98404-1-RR, Clone: 243120H8) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 488 Anti-Mouse CD19. Cells were not fixed.

• 

  FC experiment of mouse splenocytes using 98404-1-RR

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD268/BAFF-R Rabbit RecAb (98404-1-RR, Clone: 243120H8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Splenozyten

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98404-1-RR bindet in FC CD268/BAFF-R und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD268/BAFF-R fusion protein Eg1840
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 13c
• Berechnetes Molekulargewicht: 19 kDa
• GenBank-Zugangsnummer: NM_028075.2
• Gene symbol: Tnfrsf13c
• Gene ID (NCBI): 72049
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

B-cell-activating factor receptor (BAFF-R, also known as CD268 and TNFRSF13C) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in most malignant B cells, including those in primary central nervous system lymphoma (PCNSL), and is involved in the survival and proliferation of these cells (PMID: 32528875). The interaction of BAFF with BAFF-R promotes NF-κB activation, which plays a crucial role in B-cell maturation, survival, and costimulation of T-cell activation and proliferation (PMID: 30349534). Additionally, BAFF-R is associated with chronic kidney disease (CKD) by activating NF-κB signaling in renal tubular epithelial cells (PMID: 38791453).