B7-H3/CD276 Monoklonaler Antikörper

B7-H3/CD276 Monoklonal Antikörper für FC

Wirt / Isotyp

Ratte / IgG1, kappa

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

CoraLite® Plus 405 Fluorescent Dye

CloneNo.

MJ18

Kat-Nr. : CL405-65221

Synonyme

CD276, CD276 antigen, B7RP 2, B7-H3, B7h3

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  FC experiment of BALB/c mouse peritoneal macrophages using CL405-65221

  1X10^6 BALB/c mouse peritoneal macrophages were surface stained with 0.5 ug CoraLite® Plus 405 Anti-Mouse CD276 (CL405-65221, Clone: MJ18) or unstained. Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Balb/c peritoneale Makrophagen der Maus

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

CL405-65221 bindet in FC B7-H3/CD276 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Ratte / IgG1, kappa
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Mouse IgG2a Fc-CD276 (aa 1-242) fusion protein
• Vollständiger Name: CD276 antigen
• GenBank-Zugangsnummer: BC019436
• Gene symbol: Cd276
• Gene ID (NCBI): 102657
• Konjugation: CoraLite® Plus 405 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 399 nm / 422 nm
• Form: Liquid
• Reinigungsmethode: Affinitätsreinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

CD276 (also known as B7-H3) is a type I transmembrane protein expressed on many tissues and cell types. CD276 is a 100-kDa glycoprotein that belongs to the B7 immunoregulatory family and participates in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 25567370; 20696859). Overexpressed on a wide range of human solid cancers, CD276 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063).