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CD28 Rekombinanter Antikörper

CD28 Rekombinant Antikörper für IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241707H6

Kat-Nr. : 84368-4-PBS

Synonyme

241707H6, CD28 antigen, T-cell-specific surface glycoprotein CD28

Filter:
  • Immunofluorescence (IF) / fluorescent staining of EL-4-B5 cells using CD28 Recombinant antibody (84368-4-RR)

    IF Staining of EL-4-B5 using 84368-4-RR (same clone as 84368-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed EL-4-B5 cells using CD28 antibody (84368-4-RR, Clone: 241707H6 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84368-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84368-4-PBS bindet in IF/ICC, Indirect ELISA CD28 und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen CD28 fusion protein Eg1408
Vollständiger Name CD28 antigen
Berechnetes Molekulargewicht25 kDa
GenBank-ZugangsnummerNM_007642.4
Gene symbol Cd28
Gene ID (NCBI) 12487
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CD28 (T-cell-specific surface glycoprotein CD28), also known as T44 and Tp44, is a 44 kD disulfide-linked homodimeric type I glycoprotein (PMID: 2162180). It is a member of the immunoglobulin superfamily and is expressed on most T lineage cells, NK cell subsets, and plasma cells (PMID: 2162180, 8386518). CD28 may affect in vivo immune responses by functioning both as a cell adhesion molecule linking B and T lymphocytes and as the surface component of a novel signal transduction pathway (PMID: 2162180, 3021470). CD28 binds both CD80 and CD86 with a highly conserved motif MYPPY in the CDR3-like loop (PMID: 15696168, 7964482). CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death (PMID: 1348520).