CD2BP2 Polyklonaler Antikörper

CD2BP2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

Konjugation

Unkonjugiert

Kat-Nr. : 32930-1-PBS

Synonyme

CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 Cytoplasmic Tail Binding Protein 2, CD2 tail-binding protein 2, KIAA1178

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  WB analysis using 32930-1-AP (same clone as 32930-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32930-1-AP (CD2BP2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32930-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

32930-1-PBS bindet in CD2BP2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CD2BP2 fusion protein Ag38662
• Vollständiger Name: CD2 (cytoplasmic tail) binding protein 2
• Berechnetes Molekulargewicht: 38kDa，341aa
• Beobachtetes Molekulargewicht: 50 kDa
• GenBank-Zugangsnummer: NM_001243646.1
• Gene symbol: CD2BP2
• Gene ID (NCBI): 10421
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CD2BP2 (CD2-binding protein 2) is a multifunctional protein that was initially identified as a binding partner of the T-cell surface antigen CD2. It binds to the cytoplasmic tail of CD2 through its C-terminal GYF domain in the cytoplasm, regulating CD2-mediated T-lymphocyte activation. Additionally, CD2BP2 is a component of the U5 small nuclear ribonucleoprotein complex (snRNP), participating in the RNA splicing process. Studies have shown that CD2BP2 plays a crucial role in embryonic development; its absence leads to delayed embryonic growth, vascularization defects, and death by embryonic day 10.5. Specific depletion of CD2BP2 in renal podocytes results in proteinuria and ultimately fatal renal failure.