CD30 Ligand/TNFSF8 Rekombinanter Antikörper

CD30 Ligand/TNFSF8 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

CoraLite®594 Fluorescent Dye

CloneNo.

241012G10

Kat-Nr. : CL594-98113

Synonyme

Tnfsf8, 241012G10, CD30 ligand, CD30-L, Tumor necrosis factor ligand superfamily member 8

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  FC experiment of mouse splenocytes using CL594-98113

  1x10^6 untreated or anti-CD3/CD28 treated mouse splenocytes were surface stained with CoraLite® Plus 488 Anti-Mouse CD4 and 0.25 ug CoraLite®594 Anti-Mouse CD30 Ligand/TNFSF8 Rabbit RecAb (CL594-98113, Clone: 241012G10). Cells were not fixed.

• 

  FC experiment of mouse splenocytes using CL594-98113

  1x10^6 anti-CD3/CD28 treated mouse splenocytes were surface stained with 0.25 ug CoraLite®594 Anti-Mouse CD30 Ligand/TNFSF8 Rabbit RecAb (CL594-98113, Clone: 241012G10) (red) or CoraLite®594 Rabbit IgG Isotype Control RecAb (CL594-98136, Clone: 240953C9) (blue). 1x10^6 untreated mouse splenocytes were surface stained with 0.25 ug CoraLite®594 Anti-Mouse CD30 Ligand/TNFSF8 Rabbit RecAb (CL594-98113, Clone: 241012G10) (black, dashed). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: anti-CD3/CD28 treated mouse splenocytes

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

CL594-98113 bindet in FC CD30 Ligand/TNFSF8 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD30 Ligand/TNFSF8 fusion protein Eg0667
• Vollständiger Name: tumor necrosis factor (ligand) superfamily, member 8
• Berechnetes Molekulargewicht: 27 kDa
• GenBank-Zugangsnummer: NM_009403.3
• Gene symbol: Tnfsf8
• Gene ID (NCBI): 21949
• Konjugation: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

CD30 Ligand (CD30L), also named as TNFSF8 or CD153, is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) superfamily (PMID: 8391931). It is expressed on the surface of activated T cells, B cells, monocytes, macrophages, eosinophils, neutrophils, and mast cells (PMID: 26090498). CD30L interacts with its receptor, CD30, which is a cell surface protein expressed on a small subset of activated T and B lymphocytes, and a variety of lymphoid neoplasms, with the highest expression in classical Hodgkin lymphoma and anaplastic large cell lymphomas (PMID: 28885612). The CD30/CD30L signaling is involved in pleiotropic downstream effects including differentiation, cell survival and death, NFkB activation, and production of cytokines (PMID: 38534788).