CD31 Monoklonaler Antikörper
CD31 Monoklonal Antikörper für WB, IHC, IF/ICC, IF-P, Cytometric bead array, Indirect ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human
Anwendung
WB, IHC, IF/ICC, IF-P, Cytometric bead array, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
3F8E2
Kat-Nr. : 66065-2-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
66065-2-PBS bindet in WB, IHC, IF/ICC, IF-P, Cytometric bead array, Indirect ELISA CD31 und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Maus / IgG1 |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | CD31 fusion protein Ag19730 |
Vollständiger Name | platelet/endothelial cell adhesion molecule |
Berechnetes Molekulargewicht | 83 kDa |
Beobachtetes Molekulargewicht | 120-130 kDa |
GenBank-Zugangsnummer | BC022512 |
Gene symbol | CD31 |
Gene ID (NCBI) | 5175 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-G-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).