CD31 Rekombinanter Antikörper

CD31 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

251101E6

Kat-Nr. : 98533-1-PBS

Synonyme

EndoCAM, GPIIA, GPIIA', PECA1, PECAM 1

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  FC experiment of human PBMCs using 98533-1-RR (same clone as 98533-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD31 Rabbit RecAb (98533-1-RR, Clone: 251101E6) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD14. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98533-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98533-1-RR (same clone as 98533-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD31 Rabbit RecAb (98533-1-RR, Clone: 251101E6) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98533-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98533-1-PBS bindet in FC CD31 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD31 fusion protein Eg4658
• Vollständiger Name: platelet/endothelial cell adhesion molecule
• Berechnetes Molekulargewicht: 83 kDa
• GenBank-Zugangsnummer: NM_000442.5
• Gene symbol: CD31
• Gene ID (NCBI): 5175
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD31, also known as PECAM1 (Platelet endothelial cell adhesion molecule), is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. It is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, CD31 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).