CD314/NKG2D Rekombinanter Antikörper

CD314/NKG2D Rekombinant Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

1D11

Kat-Nr. : 65643-1-PBS

Synonyme

KLRK1, CD314, 1D11, KLR, Killer cell lectin-like receptor subfamily K member 1

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  FC experiment of human PBMCs using 65643-1-MR (same clone as 65643-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD314/NKG2D (1D11) Mouse IgG2a Recombinant Antibody (65643-1-MR, Clone:1D11) or Mouse IgG2a Isotype Control, and PE-conjugated Goat Anti-Mouse IgG. Cells were co-stained with CoraLite® Plus 647 Anti-Human CD8 (UCHT4) Mouse IgG2a Recombinant Antibody. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65643-1-PBS in a different storage buffer formulation.

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  FC experiment of human PBMCs using 65643-1-MR (same clone as 65643-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD314/NKG2D (1D11) Mouse IgG2a Recombinant Antibody (65643-1-MR, Clone:1D11) (red) or Mouse IgG2a Isotype Control (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65643-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

65643-1-PBS bindet in FC CD314/NKG2D und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: NKL-Zelllinie
• Vollständiger Name: killer cell lectin-like receptor subfamily K, member 1
• Berechnetes Molekulargewicht: 25 kDa
• GenBank-Zugangsnummer: BC039836
• Gene symbol: KLRK1
• Gene ID (NCBI): 22914
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD314, also known as NKG2D or Killer cell lectin-like receptor subfamily K member 1 (KLRK1), is a type II lectin-like transmembrane stimulatory receptor (PMID: 8436421). In humans, it is expressed on NK cells, gamma delta T cells, and CD8+ alpha beta T cells (PMID: 10426993). Various families of cell surface ligands have been identified, including the MICA/MICB and ULBP proteins (PMID: 12150888). CD314 is involved in both innate and adaptive immunities, and the NKG2D/NKG2DL pathway involves multiple effector cell types for controlling tumor progression (PMID: 31720075).