CD314/NKG2D Rekombinanter Antikörper

CD314/NKG2D Rekombinant Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Biotin

CloneNo.

1D11

Kat-Nr. : Biotin-65643

Synonyme

KLRK1, CD314, 1D11, KLR, Killer cell lectin-like receptor subfamily K member 1

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  FC experiment of human PBMCs using Biotin-65643

  1x10^6 human PBMCs were surface stained with 0.25 ug Biotin Anti-Human CD314/NKG2D (1D11) Mouse IgG2a RecAb (Biotin-65643, Clone:1D11) and CoraLite®488-conjugated streptavidin, or unstained. Cells were co-stained with CoraLite® Plus 647 Anti-Human CD8 (UCHT4) Mouse IgG2a Recombinant Antibody (CL647-65559, Clone: UCHT4). Cells were not fixed.

• 

  FC experiment of human PBMCs using Biotin-65643

  1x10^6 human PBMCs were surface stained with 0.25 ug Biotin Anti-Human CD314/NKG2D (1D11) Mouse IgG2a RecAb (Biotin-65643, Clone:1D11) and CoraLite®488-conjugated streptavidin (red) or unstained (blue). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: humane PBMCs

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

Biotin-65643 bindet in FC CD314/NKG2D und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: NKL-Zelllinie
• Vollständiger Name: killer cell lectin-like receptor subfamily K, member 1
• Berechnetes Molekulargewicht: 25 kDa
• GenBank-Zugangsnummer: BC039836
• Gene symbol: KLRK1
• Gene ID (NCBI): 22914
• Konjugation: Biotin
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

CD314, also known as NKG2D or Killer cell lectin-like receptor subfamily K member 1 (KLRK1), is a type II lectin-like transmembrane stimulatory receptor (PMID: 8436421). In humans, it is expressed on NK cells, gamma delta T cells, and CD8+ alpha beta T cells (PMID: 10426993). Various families of cell surface ligands have been identified, including the MICA/MICB and ULBP proteins (PMID: 12150888). CD314 is involved in both innate and adaptive immunities, and the NKG2D/NKG2DL pathway involves multiple effector cell types for controlling tumor progression (PMID: 31720075).