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E-cadherin Rekombinanter Antikörper

E-cadherin Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Ratte

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242018A7

Kat-Nr. : 98323-1-PBS

Synonyme

242018A7, Cadherin-1, CD324, Cdh1, E-Cad/CTF1

Filter:
  • Flow cytometry (FC) experiment of PC-12 cells using Anti-Rat E-cadherin Rabbit Recombinant Antibody (98323-1-RR)

    FC experiment of PC-12 using 98323-1-RR (same clone as 98323-1-PBS)

    1x10^6 PC-12 cells were surface stained with 0.25 ug Anti-Rat E-cadherin Rabbit RecAb (98323-1-RR, Clone: 242018A7) (red),or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue)and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98323-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

98323-1-PBS bindet in FC E-cadherin und zeigt Reaktivität mit Ratten

Getestete Reaktivität Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen E-cadherin fusion protein Eg1229
Vollständiger Name cadherin 1
Berechnetes Molekulargewicht99 kDa
GenBank-ZugangsnummerNM_031334.1
Gene symbol Cdh1
Gene ID (NCBI) 83502
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CD324, CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice(PMID:23509752). E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.