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CD35 Polyklonaler Antikörper

CD35 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30057-1-PBS

Synonyme

KN, CR1, Complement receptor type 1, C3BR, C3b/C4b receptor

Filter:
  • Western Blot (WB) analysis of various lysates using CD35 Polyclonal antibody (30057-1-AP)

    WB analysis using 30057-1-AP (same clone as 30057-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30057-1-AP (CD35 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30057-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30057-1-PBS bindet in WB, Indirect ELISA CD35 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CD35 fusion protein Ag30243
Vollständiger Name complement component (3b/4b) receptor 1 (Knops blood group)
Berechnetes Molekulargewicht 224 kDa
Beobachtetes Molekulargewicht250 kDa
GenBank-ZugangsnummerNM_000573
Gene symbol CR1
Gene ID (NCBI) 1378
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CD35, also known as complement receptor type 1 (CR1) or C3b/C4b receptor, is a single-chain glycoprotein consisting of 30 repeating homologous protein domains known as short consensus repeats (~60 amino acids each) followed by transmembrane and cytoplasmic domains (PMID: 8765013). CD35 is variably expressed by granulocytes, monocytes, B cells, some T cells, erythrocytes, follicular dendritic cells, Langerhans cells, and glomerular podocytes (PMID: 19004497). CD35 acts as a receptor for C3b and C4b and plays important roles in the regulation of the complement cascade and clearance of immune complexes. A soluble form of CD35 has been found in plasma (PMID: 3156931). It has been reported that soluble CD35 is produced by a proteolytic cleavage in the C-terminal region of CD35 transmembrane domain (PMID: 9405292).