CD41 Monoklonaler Antikörper

CD41 Monoklonal Antikörper für FC

Wirt / Isotyp

Ratte / IgG1, kappa

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

MWReg30

Kat-Nr. : 65189-1-Ig

Synonyme

Itga2b, GpIIb, integrin alpha 2b, MWReg30

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  FC experiment of C57BL/6 mouse peripheral blood platelets using 65189-1-Ig

  1x10^6 C57BL/6 mouse peripheral blood platelets were surface stained with 0.5 ug Anti-Mouse CD41 (65189-1-Ig, Clone: MWReg30) and FITC anti-rat IgG1 Antibody (red), or 0.5 ug Rat IgG1 Isotype Control (HRPN) (65212-1-Ig, Clone: HRPN) and FITC anti-rat IgG1 Antibody (blue). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: C57BL/6 mouse peripheral blood platelets

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

65189-1-Ig bindet in FC CD41 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Ratte / IgG1, kappa
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Mouse platelets
• Vollständiger Name: integrin alpha 2b
• GenBank-Zugangsnummer: BC120493
• Gene symbol: CD41
• Gene ID (NCBI): 16399
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Mit Protein-G-Affinitätschromatographie aufgereinigt
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2-8°C. Stable for one year after shipment.

Hintergrundinformationen

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen.