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CD41 Monoklonaler Antikörper

CD41 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

6D7C5

Kat-Nr. : 60350-1-PBS

Synonyme

CD41a, 6D7C5, CD41B, GP2B, GPalpha IIb

Filter:
  • Western Blot (WB) analysis of human spleen tissue using CD41 Monoclonal antibody (60350-1-Ig)

    WB analysis of human spleen using 60350-1-Ig (same clone as 60350-1-PBS)

    human spleen tissue were subjected to SDS PAGE followed by western blot with 60350-1-Ig (CD41/Integrin alpha 2b Antibody) at dilution of 1:1600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60350-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

60350-1-PBS bindet in WB, Indirect ELISA CD41 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Berechnetes Molekulargewicht 113 kDa
Beobachtetes Molekulargewicht 125 kDa
GenBank-ZugangsnummerBC126442
Gene symbol CD41
Gene ID (NCBI) 3674
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen.