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CD42b Rekombinanter Antikörper

CD42b Rekombinant Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

AK2

Kat-Nr. : 65588-1-PBS

Synonyme

GP1BA, GP1B, CD42b alpha, BSS, Antigen CD42b-alpha

Filter:
  • Flow cytometry (FC) experiment of human peripheral blood platelets using Anti-Human CD42b (AK2) Mouse IgG2a Recombinant Ant (65588-1-MR)

    FC experiment of human peripheral blood platelets using 65588-1-MR (same clone as 65588-1-PBS)

    1x10^6 human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD42b Mouse IgG2a Recombinant Antibody (65588-1-MR, Clone: AK2) (red) or Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) (blue) and CoraLite®488-Conjugated AffiniPure Donkey Anti-Mouse IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 65588-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

65588-1-PBS bindet in FC CD42b und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2a
Klonalität Rekombinant
Typ Antikörper
Immunogen Humane Thrombozyten
Vollständiger Name glycoprotein Ib (platelet), alpha polypeptide
Berechnetes Molekulargewicht 626 aa, 69 kDa
GenBank-ZugangsnummerBC027955
Gene symbol CD42b
Gene ID (NCBI) 2811
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

CD42b, also known as platelet glycoprotein Ib alpha chain (GPIb alpha), is a type I transmembrane glycoprotein of 135-145 kDa (PMID: 2656709). It is expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are linked by a disulphide bond to form GPIb (PMID: 7660135). GPIb forms a noncovalent complex with CD42a (GPIX) and CD42d (GPV) and acts as a receptor for von Willebrand factor (vWF) and thrombin (PMID: 7660135; 3759960). The GPIb-V-IX complex mediates vWF-dependent platelet adhesion to blood vessels. Defects in the expression of CD42b result in Bernard-Soulier syndromes and platelet-type von Willebrand disease (PMID: 9371310).