CD44 Rekombinanter Antikörper

CD44 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Ratte

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241648F8

Kat-Nr. : 98208-1-PBS

Synonyme

241648F8, CD44 antigen, ECMR-III, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor

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  FC experiment of rat splenocytes using 98208-1-RR (same clone as 98208-1-PBS)

  1x10^6 rat splenocytes were surface stained with 0.25 ug Anti-Rat CD44 Rabbit Recombinant Antibody (98208-1-RR, Clone: 241648F8) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98208-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98208-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98208-1-RR against Rat CD44 were performed. The affinity constant is 1.02 nM.

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Geprüfte Anwendungen

Produktinformation

98208-1-PBS bindet in FC CD44 und zeigt Reaktivität mit Ratten

• Getestete Reaktivität: Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD44 fusion protein Eg1458
• Vollständiger Name: Cd44 molecule
• Berechnetes Molekulargewicht: 40 kDa
• GenBank-Zugangsnummer: XM_006234631.3
• Gene symbol: Cd44
• Gene ID (NCBI): 25406
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD44 is a type I transmembrane glycoprotein expressed on embryonic stem cells and in various levels on other cell types including connective tissues and bone marrow. CD44 expression is also upregulated in subpopulations of cancer cells and is recognized as a molecular marker for cancer stem cells (PMID: 29747682). It is a cell-surface receptor that mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands (PMID: 10694938). Adhesion with HA plays an important role in cell migration, tumor growth and progression. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis.