CD44 Rekombinanter Antikörper

CD44 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242666F8

Kat-Nr. : 98359-2-PBS

Synonyme

242666F8, CD44 antigen, CDw44, CSPG8, ECMR III

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  FC experiment of mouse splenocytes using 98359-2-RR (same clone as 98359-2-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.125 ug Anti-Mouse CD44 Rabbit RecAb (98359-2-RR, Clone: 242666F8) or 0.125 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Mouse CD62L. Cells were not fixed. This data was developed using the same antibody clone with 98359-2-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98359-2-RR (same clone as 98359-2-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.125 ug Anti-Mouse CD44 Rabbit RecAb (98359-2-RR, Clone: 242666F8) (red) or 0.125 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98359-2-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98359-2-PBS bindet in FC CD44 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD44 fusion protein Eg3159
• Vollständiger Name: CD44 antigen
• Berechnetes Molekulargewicht: 86 kDa
• GenBank-Zugangsnummer: NM_009851.2
• Gene symbol: Cd44
• Gene ID (NCBI): 12505
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD44 is a type I transmembrane glycoprotein expressed on embryonic stem cells and in various levels on other cell types including connective tissues and bone marrow. CD44 expression is also upregulated in subpopulations of cancer cells and is recognized as a molecular marker for cancer stem cells (PMID: 29747682). It is a cell-surface receptor that mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands (PMID: 10694938). Adhesion with HA plays an important role in cell migration, tumor growth and progression. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis.