CD46 Rekombinanter Antikörper

CD46 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

PerCP Fluorescent Dye

CloneNo.

241764C9

Kat-Nr. : CP-98240

Synonyme

MCP, Membrane cofactor protein, MIC10, TLX, TRA2.10

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  FC experiment of human PBMCs using CP-98240

  1x10^6 human PBMCs were surface stained with CoraLite® Plus 647 Anti-Human CD19, and 5 ul PerCP Anti-Human CD46 Rabbit RecAb (CP-98240, Clone: 241764C9) or unstained. Cells were not fixed.

• 

  FC experiment of human PBMCs using CP-98240

  1x10^6 human PBMCs were surface stained with 5 ul PerCP Anti-Human CD46 Rabbit RecAb (CP-98240, Clone: 241764C9) (red) or unstained (blue). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: humane PBMCs

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Produktinformation

CP-98240 bindet in FC CD46 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD46 fusion protein Eg1770
• Vollständiger Name: CD46 molecule, complement regulatory protein
• Berechnetes Molekulargewicht: 42kDa
• GenBank-Zugangsnummer: NM_172351.3
• Gene symbol: CD46
• Gene ID (NCBI): 4179
• Konjugation: PerCP Fluorescent Dye
• Excitation/Emission maxima wavelengths: 482 nm / 677 nm
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

CD46, also known as Membrane cofactor protein (MCP) or MIC10, is a ubiquitously expressed type type-I transmembrane glycoprotein that acts as a cofactor for complement factor I to mediate inactivation of C3b and C4b deposited on host cells. CD46 is a receptor for a large number of pathogens, including measles virus and adenovirus (PMID: 20941397). CD46 plays a role in linking innate and adaptive immune responses. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations of the CD46 gene have been associated with some diseases including hemolytic uremic syndrome (PMID: 26054645). CD46 is expressed on most cells as four isoforms that are derived via alternative splicing (PMID: 15324743).