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CD48 Rekombinanter Antikörper

CD48 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241389F9

Kat-Nr. : 84186-5-PBS

Synonyme

CD48 molecule, CD48 antigen, B-lymphocyte activation marker BLAST-1, BLAST1, BLAST

Filter:
  • Western Blot (WB) analysis of various lysates using CD48 Recombinant antibody (84186-5-RR)

    WB analysis using 84186-5-RR (same clone as 84186-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84186-5-RR (CD48 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84186-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84186-5-RR

    Affinity and Kinetic Characterization of 84186-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84186-5-RR against Human CD48 were performed. The affinity constant is 0.672 nM.

Geprüfte Anwendungen

Produktinformation

84186-5-PBS bindet in WB, Indirect ELISA CD48 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Fusionsprotein
Vollständiger Name CD48 molecule
Berechnetes Molekulargewicht 43 kDa
Beobachtetes Molekulargewicht40-45 kDa
GenBank-ZugangsnummerBC016182
Gene symbol CD48
Gene ID (NCBI) 962
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Signaling lymphocytic activation molecule family 2 (SLAMF2, CD48) is an adhesion and costimulatory molecule expressed constitutively on most hematopoietic cells, particularly in antigen-presenting cells (APC). CD48 is expressed on all the hematopoietic cells, both in humans and mice, except for murine neutrophils and long-term HSC. CD48 exists as both a membrane-bound (mCD48) and a soluble (sCD48) form. CD48 can activate T cells, antigen-presenting cells and granulocytes, by binding to CD2 or bacterial FimH, and through cell intrinsic effects. Interactions between CD48 and its high-affinity ligand CD244 are more complex, with both stimulatory and inhibitory outcomes. CD48 expression is increased in autoimmunity and allergy diseases, and anti-CD48 monoclonal antibodies have been shown to attenuate experimental autoimmune encephalomyelitis.