CD49b Rekombinanter Antikörper

CD49b Rekombinant Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

AK7

Kat-Nr. : 65583-1-MR

Synonyme

ITGA2, AK7, BR, Collagen receptor, GPIa

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  FC experiment of human peripheral blood platelets using 65583-1-MR

  1x10^6 human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD49b (AK7) Mouse IgG2a RecAb (65583-1-MR, Clone: AK7) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: human peripheral blood platelets

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

65583-1-MR bindet in FC CD49b und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Humane Thrombozyten
• Vollständiger Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
• Berechnetes Molekulargewicht: 126 kDa
• GenBank-Zugangsnummer: NM_002203
• Gene symbol: Integrin alpha 2
• Gene ID (NCBI): 3673
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2-8°C. Stable for one year after shipment.

Hintergrundinformationen

CD49b, also known as alpha2 integrin, is a type I transmembrane glycoprotein which forms an adhesion molecule VLA-2 with beta1 integrin. CD49b is a receptor for many (extracellular) matrix and non-matrix molecules (PMID: 23847623). CD49b is expressed on numerous cell types including platelets, activated T cells, B cells, and monocytes. CD49b activation skews NK cell effector function to a phenotype that exhibits elevated IFN-γ production with a concomitant inhibition of motility and cytolytic function (PMID: 32971468, 32762681). The Anti-Human CD49b antibody, clone AK7, is derived from Human platelets.