CD49b Rekombinanter Antikörper

CD49b Rekombinant Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

AK7

Kat-Nr. : 65583-1-PBS

Synonyme

ITGA2, AK7, BR, Collagen receptor, GPIa

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  FC experiment of human peripheral blood platelets using 65583-1-MR (same clone as 65583-1-PBS)

  1x10^6 human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD49b (AK7) Mouse IgG2a RecAb (65583-1-MR, Clone: AK7) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed. This data was developed using the same antibody clone with 65583-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

65583-1-PBS bindet in FC CD49b und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Humane Thrombozyten
• Vollständiger Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
• Berechnetes Molekulargewicht: 126 kDa
• GenBank-Zugangsnummer: NM_002203
• Gene symbol: Integrin alpha 2
• Gene ID (NCBI): 3673
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD49b, also known as alpha2 integrin, is a type I transmembrane glycoprotein which forms an adhesion molecule VLA-2 with beta1 integrin. CD49b is a receptor for many (extracellular) matrix and non-matrix molecules (PMID: 23847623). CD49b is expressed on numerous cell types including platelets, activated T cells, B cells, and monocytes. CD49b activation skews NK cell effector function to a phenotype that exhibits elevated IFN-γ production with a concomitant inhibition of motility and cytolytic function (PMID: 32971468, 32762681). The Anti-Human CD49b antibody, clone AK7, is derived from Human platelets.