Integrin alpha 6 Rekombinanter Antikörper

Integrin alpha 6 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241703B5

Kat-Nr. : 98257-1-PBS

Synonyme

ITGA6, 241703B5, CD49 antigen-like family member F, CD49f, Integrin alpha-6

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  FC experiment of human peripheral blood lymphocytes using 98257-1-RR (same clone as 98257-1-PBS)

  1x10^6 human peripheral blood lymphocytes were surface stained with 0.25 ug Anti-Human CD49f/Integrin alpha 6 Rabbit Recombinant Antibody (98257-1-RR, Clone: 241703B5) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with APC Anti-Human CD61. Cells were not fixed. This data was developed using the same antibody clone with 98257-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human peripheral blood lymphocytes using 98257-1-RR (same clone as 98257-1-PBS)

  1x10^6 human peripheral blood lymphocytes were surface stained with 0.25 ug Anti-Human CD49f/Integrin alpha 6 Rabbit Recombinant Antibody (98257-1-RR, Clone: 241703B5) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98257-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98257-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98257-1-RR against Human CD49f/Integrin alpha 6 were performed. The affinity constant is 0.400 nM.

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Geprüfte Anwendungen

Produktinformation

98257-1-PBS bindet in FC Integrin alpha 6 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: integrin, alpha 6
• Berechnetes Molekulargewicht: 1073 aa, 119 kDa
• GenBank-Zugangsnummer: BC136456
• Gene symbol: Integrin alpha 6
• Gene ID (NCBI): 3655
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 6 (ITGA6, also known as CD49f or VLA-6) is a 120-kDa single-pass type 1 transmembrane glycoprotein, which combines with the beta 1 subunit (ITGB1, CD29) or beta 4 subunit (ITGB4, CD104) to form heterodimeric laminin receptors (PMID: 1976638; 2351695). Integrin alpha 6 mediates cell-to-cell and cell-to-stroma adhesion. It has also been found in many different stem cell populations and is involved in homing and connecting stem cells to their niches and regulating self-renewal mechanisms in stem cells (PMID: 28494695).