CD55 Rekombinanter Antikörper

CD55 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250682C11

Kat-Nr. : 98493-3-PBS

Synonyme

Complement decay-accelerating factor, CR, CROM, DAF, TC

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  FC experiment of human blood using 98493-3-RR (same clone as 98493-3-PBS)

  1x10^6 human blood cells were surface stained with 0.25 ug Anti-Human CD55 Rabbit RecAb (98493-3-RR, Clone: 250682C11) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98493-3-PBS in a different storage buffer formulation.

• 

  FC experiment of human blood using 98493-3-RR (same clone as 98493-3-PBS)

  1x10^6 human blood cells were surface stained with 0.25 ug Anti-Human CD55 Rabbit RecAb (98493-3-RR, Clone:250682C11) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98493-3-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98493-3-PBS bindet in FC CD55 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD55 fusion protein Eg4246
• Vollständiger Name: CD55 molecule, decay accelerating factor for complement (Cromer blood group)
• Berechnetes Molekulargewicht: 41 kDa
• GenBank-Zugangsnummer: BC001288
• Gene symbol: CD55
• Gene ID (NCBI): 1604
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD55, also known as DAF, is a glycosylphosphatidylinositol (GPI)-anchored surface glycoprotein that is widely distributed on blood, stroma, epithelial, and endothelial cells (PMID: 7517044; 29503741). It can also exist as a soluble form in plasma, urine, saliva, tears, and synovial fluids (PMID: 29503741). CD55 is a complement regulatory protein (PMID: 2469439; 7517044). It inhibits formation of the C3 convertases through binding to C3b and C4b. It also binds the alternate pathway convertase C3bBb, the classical pathway convertase and C4b2a to accelerate their decay (PMID: 17289551). CD55 also serves as a receptor for coxsackieviruses B1, B3, and B5 and several enteroviruses (PMID: 7538177; 7517044).