CD6 Rekombinanter Antikörper

CD6 Rekombinant Antikörper für Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test

Konjugation

Unkonjugiert

CloneNo.

241965B11

Kat-Nr. : 84508-2-PBS

Synonyme

CD6 molecule, Soluble CD6, T12, T-cell differentiation antigen CD6, TP120

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  Sandwich ELISA standard curve of MP01358-2

  Sandwich ELISA standard curve of MP01358-2, Human CD6 Recombinant Matched Antibody Pair - PBS only. 84508-1-PBS was coated to a plate as the capture antibody and incubated with serial dilutions of standard Eg2079. 84508-2-PBS was HRP conjugated as the detection antibody. Range: 78.1-5000 pg/mL.

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  Sample test of MP01358-2

  The mean CD6 concentration was determined to be 20.8 ng/mL in MOLT-4 cell extract based on a 1.2 mg/mL extract load and 10.9 ng/mL in Jurkat cell extract based on a 4.2 mg/mL extract load.

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  Sample test of MP01358-2

  Serum of six individual healthy human donors was measured. The CD6 concentration of detected samples was determined to be 2,345.6 pg/mL with a range of 1,106.3-6,008.2 pg/mL.

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  Cytometric bead array standard curve of MP01358-2

  Cytometric bead array standard curve of MP01358-2, CD6 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 84508-1-PBS. Detection antibody: 84508-2-PBS. Standard: Eg2079. Range: 0.781-100 ng/mL.

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  Affinity and Kinetic Characterization of 84508-2-PBS

  Biolayer interferometry (BLl) kinetic assays of 84508-2-PBS against Human CD6 were performed. The affinity constant is 35.1 pM.

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Geprüfte Anwendungen

Produktinformation

84508-2-PBS bindet in Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test CD6 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD6 fusion protein Eg2079
• Vollständiger Name: CD6 molecule
• GenBank-Zugangsnummer: BC033755
• Gene symbol: CD6
• Gene ID (NCBI): 923
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CD6 is a type I transmembrane glycoprotein of 105-130 kDa that belongs to the scavenger receptor cysteine-rich superfamily (PMID: 21880988). It is composed of an extracellular region, which consists of three tandem SRCR domains, a transmembrane region, and a cytoplasmic tail devoid of intrinsic catalytic activity but harbouring several phosphorylatable residues suitable for intracellular signal transduction (PMID: 38139340; 23711376). CD6 is expressed by T cells, medullary thymocytes, a subset of B cells and NK cells, and in some cells of the brain (PMID: 1919444; 21178331). CD6 plays a role in lymphocyte activation, proliferation, and survival processes via interaction with its endogenous ligands.