CD62P Rekombinanter Antikörper

CD62P Rekombinant Antikörper für FC

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

AK4

Kat-Nr. : 65587-1-PBS

Synonyme

P-selectin, GMRP, GMP-140, GMP140, GMP 140

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  FC experiment of human peripheral blood platelets using 65587-1-MR (same clone as 65587-1-PBS)

  1x10^6 thrombin treated human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD62P Mouse IgG2a Recombinant Antibody (65587-1-MR, Clone: AK4) (red) or Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) (blue) and CoraLite®488-Conjugated AffiniPure Donkey Anti-Mouse IgG(H+L). Untreated human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD62P Mouse IgG2a Recombinant Antibody (65587-1-MR, Clone: AK4) and CoraLite®488-Conjugated AffiniPure Donkey Anti-Mouse IgG(H+L)(black). Cells were not fixed. This data was developed using the same antibody clone with 65587-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

65587-1-PBS bindet in FC CD62P und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Humane Thrombozyten
• Vollständiger Name: selectin P (granule membrane protein 140kDa, antigen CD62)
• Berechnetes Molekulargewicht: 830 aa, 91 kDa
• GenBank-Zugangsnummer: BC028067
• Gene symbol: CD62P
• Gene ID (NCBI): 6403
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

P-selectin, also known as GMP140 or CD62P, is a transmembrane glycoprotein that mediates the interaction of activated endothelial cells or platelets with leukocytes. It is an adhesion molecule involved in the pathogenesis of inflammation, thrombosis, and oncogenesis. P-selectin is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.