CD63 Rekombinanter Antikörper

CD63 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241964E1

Kat-Nr. : 98318-1-PBS

Synonyme

Lysosome integral membrane protein 1, Lysosomal-associated membrane protein 3, Limp1, CD63 antigen, CD 63

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  FC experiment of human peripheral blood platelets using 98318-1-RR (same clone as 98318-1-PBS)

  1x10^6 Thrombin-treated human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD63 Rabbit RecAb (98318-1-RR, Clone: 241964E1) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. Untreated human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD63 Rabbit RecAb (98318-1-RR, Clone: 241964E1) and PE-conjugated Goat Anti-Rabbit IgG (black, dashed). Cells were not fixed. This data was developed using the same antibody clone with 98318-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98318-1-PBS bindet in FC CD63 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: CD63 molecule
• Berechnetes Molekulargewicht: 26 kDa
• GenBank-Zugangsnummer: BC002349
• Gene symbol: CD63
• Gene ID (NCBI): 967
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD63 is a 30-60 kDa lysosomal membrane protein that belongs to the tetraspanin family. This protein plays many important roles in immuno-physiological functions. It mediates signal transduction events that regulate cell development, activation, growth, and motility. CD63 is expressed on activated platelets, thus it may function as a blood platelet activation marker. CD63 is a lysosomal membrane glycoprotein translocated to the plasma membrane after platelet activation. The CD63 tetraspanin is highly expressed in the early stages of melanoma and decreases in advanced lesions, suggesting it is a possible suppressor of tumor progression. Deficiency of this protein is associated with Hermansky-Pudlak syndrome.