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CD70 Rekombinanter Antikörper

CD70 Rekombinant Antikörper für IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241324B12

Kat-Nr. : 84455-2-PBS

Synonyme

241324B12, CD27 L, CD27 ligand, CD27L, CD27-L

Filter:
  • Immunofluorescence (IF) / fluorescent staining of THP-1 cells using CD70 Recombinant monoclonal antibody (84455-2-RR)

    IF Staining of THP-1 using 84455-2-RR (same clone as 84455-2-PBS)

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using CD70 antibody (84455-2-RR, Clone: 241324B12 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84455-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84455-2-RR

    Affinity and Kinetic Characterization of 84455-2-RR

    Biolayer interferometry (BLl) kinetic assays of 84455-2-RR against Human CD70 were performed. The affinity constant is 67.0 pM.

Geprüfte Anwendungen

Produktinformation

84455-2-PBS bindet in IF/ICC, Indirect ELISA CD70 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name CD70 molecule
Berechnetes Molekulargewicht 21 kDa
GenBank-ZugangsnummerBC000725
Gene symbol CD70
Gene ID (NCBI) 970
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CD70, also known as tumor necrosis factor ligand superfamily member 7 (TNFSF7) or CD27 ligand (CD27L), is a transmembrane protein that plays a significant role in the immune system. It is the unique ligand for CD27, a member of the tumor necrosis factor receptor (TNFR) family, and is transiently upregulated upon stimulation of immune cells. CD70 is expressed on lymphocytes and dendritic cells, and its expression can be regulated by activation signals received via toll-like receptors (TLRs), CD40, and the antigen receptor MHC II. It provides complex and not completely understood signaling for B cell development. CD70 is also expressed on various solid tumors and hematolymphoid malignancies, where it may contribute to a poor prognosis.