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CD70 Rekombinanter Antikörper

CD70 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241325D8

Kat-Nr. : 98098-1-PBS

Synonyme

241325D8, CD27 L, CD27 ligand, CD27L, CD27-L

Filter:
  • Flow cytometry (FC) experiment of U266 cells using Anti-Human CD70 Rabbit Recombinant Antibody (98098-1-RR)

    FC experiment of U266 using 98098-1-RR (same clone as 98098-1-PBS)

    1x10^6 U266 cells were stained with 0.25 ug Anti-Human CD70 Rabbit Recombinant Antibody (98098-1-RR, Clone:241325D8) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98098-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98098-1-RR

    Affinity and Kinetic Characterization of 98098-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98098-1-RR against Human CD70 were performed. The affinity constant is 0.117 nM.

Geprüfte Anwendungen

Produktinformation

98098-1-PBS bindet in FC CD70 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name CD70 molecule
Berechnetes Molekulargewicht 21 kDa
GenBank-ZugangsnummerBC000725
Gene symbol CD70
Gene ID (NCBI) 970
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

CD70, also known as tumor necrosis factor ligand superfamily member 7 (TNFSF7) or CD27 ligand (CD27L), is a transmembrane protein that plays a significant role in the immune system. It is the unique ligand for CD27, a member of the tumor necrosis factor receptor (TNFR) family, and is transiently upregulated upon stimulation of immune cells. CD70 is expressed on lymphocytes and dendritic cells, and its expression can be regulated by activation signals received via toll-like receptors (TLRs), CD40, and the antigen receptor MHC II. It provides complex and not completely understood signaling for B cell development. CD70 is also expressed on various solid tumors and hematolymphoid malignancies, where it may contribute to a poor prognosis.