CD70 Rekombinanter Antikörper

CD70 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241325D8

Kat-Nr. : 98098-1-RR

Synonyme

241325D8, CD27 L, CD27 ligand, CD27L, CD27-L

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  FC experiment of U266 using 98098-1-RR

  1x10^6 U266 cells were stained with 0.25 ug Anti-Human CD70 Rabbit Recombinant Antibody (98098-1-RR, Clone:241325D8) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98098-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98098-1-RR against Human CD70 were performed. The affinity constant is 0.117 nM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: U266 cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98098-1-RR bindet in FC CD70 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: CD70 molecule
• Berechnetes Molekulargewicht: 21 kDa
• GenBank-Zugangsnummer: BC000725
• Gene symbol: CD70
• Gene ID (NCBI): 970
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

CD70, also known as tumor necrosis factor ligand superfamily member 7 (TNFSF7) or CD27 ligand (CD27L), is a transmembrane protein that plays a significant role in the immune system. It is the unique ligand for CD27, a member of the tumor necrosis factor receptor (TNFR) family, and is transiently upregulated upon stimulation of immune cells. CD70 is expressed on lymphocytes and dendritic cells, and its expression can be regulated by activation signals received via toll-like receptors (TLRs), CD40, and the antigen receptor MHC II. It provides complex and not completely understood signaling for B cell development. CD70 is also expressed on various solid tumors and hematolymphoid malignancies, where it may contribute to a poor prognosis.