CD80 Rekombinanter Antikörper

CD80 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242913B11

Kat-Nr. : 98384-1-PBS

Synonyme

Activation B7 1 antigen, Activation B7-1 antigen, B7, B7 1, B7-1

---

• 

  FC experiment of Raji using 98384-1-RR (same clone as 98384-1-PBS)

  1x10^6 Raji (left) or HUVEC cells (right) were surface stained with 0.25 ug Anti-Human CD80 Rabbit RecAb (98384-1-RR, Clone: 242913B11) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98384-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

98384-1-PBS bindet in FC CD80 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: CD80 molecule
• Berechnetes Molekulargewicht: 33 kDa
• GenBank-Zugangsnummer: NM_005191
• Gene symbol: CD80
• Gene ID (NCBI): 941
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD80 (also known as B7-1) is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B. (PMID: 7545666; 12015893; 16920215)