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CD89 Rekombinanter Antikörper

CD89 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241426H1

Kat-Nr. : 84384-5-PBS

Synonyme

IgA Fc receptor, FCAR, 241426H1

Filter:
  • Western Blot (WB) analysis of various lysates using CD89 Recombinant antibody (84384-5-RR)

    WB analysis using 84384-5-RR (same clone as 84384-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84384-5-RR (CD89 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84384-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84384-5-RR

    Affinity and Kinetic Characterization of 84384-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84384-5-RR against Human CD89 were performed. The affinity constant is 13.5 nM.

Geprüfte Anwendungen

Produktinformation

84384-5-PBS bindet in WB, Indirect ELISA CD89 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name Fc fragment of IgA, receptor for
Berechnetes Molekulargewicht 287 aa, 32 kDa
Beobachtetes Molekulargewicht65-70 kDa
GenBank-ZugangsnummerBC027953
Gene symbol CD89
Gene ID (NCBI) 2204
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

FcαRI (CD89) is a member of the Fc receptor immunoglobulin superfamily, constitutively expressed on cells of the myeloid lineage like neutrophils, eosinophils, monocytes macrophages, and platelets (PMID: 28103138). CD89 expression and activation are increased in human blood phagocytes following bacterial infection, together with increased expression and association of FcRγ with CD89 (PMID: 34756952). CD89 binds both subclasses of IgA (IgA1 and IgA2) with moderate affinity, but also binds other molecules such as TfR1, C-reactive protein and bacterial ligands. CD89 represents an effective target molecule for immunotherapy mediated by bispecific antibodies (PMID: 37081893).