CD98/SLC3A2 Rekombinanter Antikörper

CD98/SLC3A2 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / scFv

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Biotin

CloneNo.

241755D6

Kat-Nr. : Biotin-SF98190

Synonyme

CD98, SLC3A2, 4F2 cell-surface antigen heavy chain, Amino acid transporter heavy chain SLC3A2, MDU1

---

• 

  FC experiment of human PBMCs using Biotin-SF98190

  1x10^6 human PBMCs were surface stained with 0.25 ug Biotin Anti-Human CD98/SLC3A2 Rabbit scFv Antibody (Biotin-SF98190, Clone: 241755D6) or 0.25 ug Isotype Control, and PE Streptavidin (Cat.No. PF00021). Cells were not fixed.

• 

  FC experiment of human PBMCs using Biotin-SF98190

  1x10^6 human PBMCs were surface stained with 0.25 ug Biotin Anti-Human CD98/SLC3A2 Rabbit scFv Antibody (Biotin-SF98190, Clone: 241755D6)(red) or 0.25 ug Isotype Control (blue), and PE Streptavidin (Cat.No. PF00021). Cells were not fixed.

---

Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: humane PBMCs

Empfohlene Verdünnung

• Durchflusszytometrie (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

Biotin-SF98190 bindet in FC CD98/SLC3A2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / scFv
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CD98/SLC3A2 fusion protein Eg1948
• Vollständiger Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
• Berechnetes Molekulargewicht: 68 kDa
• GenBank-Zugangsnummer: NM_002394.5
• Gene symbol: CD98
• Gene ID (NCBI): 6520
• Konjugation: Biotin
• Excitation/Emission maxima wavelengths: -
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
• Lagerungsbedingungen: Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CD98 is a 125-kDa type II membrane glycoprotein heterodimer composed of a 40-kDa non-glycosylated light chain (amino-acid transporter, encoded by the SLC7A5) and an 85-kDa glycosylated heavy chain (CD98hc, encoded by the SLC3A2) (PMID: 11507094). CD98hc also interacts with certain integrin b-subunits to regulate cell migration, survival, proliferation, and adhesion/polarity. CD98hc is overexpressed on the cell surface of many cancers and increased CD98hc expression is associated with the development and progression of tumors.(PMID:25084765). Molecular orientation studies have demonstrated that the C-terminal tail of human CD98 (hCD98), which contains a PDZ-binding domain, is extracellular (PMID: 18625289).