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CDK8/19 Rekombinanter Antikörper

CDK8/19 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250832D1

Kat-Nr. : 86276-1-PBS

Synonyme

CDC2L6, CDC2 related protein kinase 6, CDC2-related protein kinase 6, CDK11, CDK19

Filter:
  • Western Blot (WB) analysis of various lysates using CDK8/19 Recombinant antibody (86276-1-RR)

    WB analysis using 86276-1-RR (same clone as 86276-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86276-1-RR (CDC2L6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86276-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86276-1-RR

    Affinity and Kinetic Characterization of 86276-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86276-1-RR against Human CDK8/19 were performed. The affinity constant is 3.19 nM.

Geprüfte Anwendungen

Produktinformation

86276-1-PBS bindet in WB, Indirect ELISA CDK8/19 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen CDK8/19 fusion protein Ag4731
Vollständiger Name cell division cycle 2-like 6 (CDK8-like)
Berechnetes Molekulargewicht 502 aa, 57 kDa
Beobachtetes Molekulargewicht57 kDa
GenBank-ZugangsnummerBC037289
Gene symbol CDK19
Gene ID (NCBI) 23097
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The CDK8 homolog, CDK19 (Cdk11, CDC2L6) was discovered by Hidden Markov model (HMM) profiling of a eukaryotic protein kinase domain, and found to have approximately 91% sequence homology to Cdk8. The two proteins share a particularly high degree of sequence conservation in their kinase and cyclin binding domain (PMID: 30693281, 26985305). CDK8 and CDK19, collectively termed 'Mediator Kinase,' are incorporated, in a mutually exclusive manner, as part of a 4-protein complex called the Mediator kinase module. CDK8/19 inhibition suppressed the induction of NFκB-driven transcription by p21 (PMID: 28855340).