CDY1B Polyklonaler Antikörper

CDY1B Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33231-1-AP

Synonyme

CDY1, CDY1A, EC:2.3.1.48, Testis-specific chromodomain protein Y 1

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  WB analysis using 33231-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 33231-1-AP (CDY1B antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: humanes Hodengewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

33231-1-AP bindet in WB, ELISA CDY1B und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CDY1B fusion protein Ag37962
• Vollständiger Name: chromodomain protein, Y-linked, 1B
• Berechnetes Molekulargewicht: 540 aa, 60 kDa/554 aa, 62 kDa
• Beobachtetes Molekulargewicht: 65 kDa
• GenBank-Zugangsnummer: BC132929
• Gene symbol: CDY1B
• Gene ID (NCBI): 253175
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The CDY1B gene, also known as Chromodomain Y-Linked 1B, is a Protein Coding gene located on the Y chromosome. It is one of the two identical copies of the CDY1 gene within the AZFc region of the human Y chromosome. As a histone acetyltransferase, CDY1B exhibits a strong preference for histone 4, suggesting its involvement in both spermatogenic histone replacement and DNA transcription. It plays a significant role in the chromatin remodeling of round spermatid nuclei, contributing to the transition from histone-based chromatin to protamine-based chromatin during spermatogenesis. This transition is essential for the condensation of sperm DNA and the formation of mature sperm. Deletion of either CDY1 can lead to spermatogenic failure and male infertility.