CEACAM1/CD66a Rekombinanter Antikörper

CEACAM1/CD66a Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241856H5

Kat-Nr. : 98185-1-PBS

Synonyme

Biliary glycoprotein D, Biliary glycoprotein 1, BGP-1, Bgp1, Bgp

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  FC experiment of mouse splenocytes using 98185-1-RR (same clone as 98185-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CEACAM1/CD66a Rabbit Recombinant Antibody (98185-1-RR, Clone: 241856H5) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Mouse CD45R. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98185-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98185-1-RR (same clone as 98185-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CEACAM1/CD66a Rabbit Recombinant Antibody (98185-1-RR, Clone: 241856H5) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Mouse CD45R. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98185-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98185-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98185-1-RR against Mouse CEACAM1/CD66a were performed. The affinity constant is below 1 pM.

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Geprüfte Anwendungen

Produktinformation

98185-1-PBS bindet in FC CEACAM1/CD66a und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: carcinoembryonic antigen-related cell adhesion molecule 1
• Berechnetes Molekulargewicht: 57 kDa
• Gene symbol: Ceacam1
• Gene ID (NCBI): 26365
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CEACAM1, also known as CD66a or BGP (biliary glycoprotein), is a member of the cacinoembryonic antigen (CEA) family which belongs to the immunoglobulin superfamily of cell adhesion molecules (PMID: 16919437). CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in the control of cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). CEACAM1 is a transmembrane glycoprotein that is expressed on epithelial, endothelial, and immune cells (PMID: 30314283). CEACAM1 has been demonstrated to play a role in morphogenesis, apoptosis, angiogenesis, cell proliferation, cell motility, fibrosis, and immunity (PMID: 31604530).