CEACAM1/3/6 (CD66a/c/d) Rekombinanter Antikörper

CEACAM1/3/6 (CD66a/c/d) Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

240497E12

Kat-Nr. : 98061-1-PBS

Synonyme

CEACAM1, CEACAM1/CD66a, Biliary glycoprotein 1, BGPI, BGP-1

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  FC experiment of human peripheral blood leukocytes using 98061-1-RR (same clone as 98061-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM1/3/6 (CD66a/c/d) Rabbit Recombinant Antibody (98061-1-RR, Clone:240497E12) or Isotype Control and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with APC Anti-Human CD16. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98061-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human peripheral blood leukocytes using 98061-1-RR (same clone as 98061-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM1/3/6 (CD66a/c/d) Rabbit Recombinant Antibody (98061-1-RR, Clone:240497E12) (red) or Isotype Control (blue) and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98061-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98061-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98061-1-RR against Human CEACAM1/CD66a were performed. The affinity constant is 4.34 nM.

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Geprüfte Anwendungen

Produktinformation

98061-1-PBS bindet in FC CEACAM1/3/6 (CD66a/c/d) und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
• Berechnetes Molekulargewicht: 526 aa, 58 kDa
• GenBank-Zugangsnummer: BC014473
• Gene symbol: CEACAM1
• Gene ID (NCBI): 634
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CEACAM1, also known as CD66a or BGP (biliary glycoprotein), is a member of the cacinoembryonic antigen (CEA) family which belongs to the immunoglobulin superfamily of cell adhesion molecules (PMID: 16919437). CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in the control of cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). CEACAM1 is a transmembrane glycoprotein that is expressed on epithelial, endothelial, and immune cells (PMID: 30314283). CEACAM1 has been demonstrated to play a role in morphogenesis, apoptosis, angiogenesis, cell proliferation, cell motility, fibrosis, and immunity (PMID: 31604530). This antibody is raised against 35-428 aa of human CEACAM1/CD66a and can cross-react with CEACAM6/CD66c and CEACAM3/CD66d.