CEACAM3/6 (CD66c/d) Rekombinanter Antikörper

CEACAM3/6 (CD66c/d) Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241254D1

Kat-Nr. : 98169-1-PBS

Synonyme

CEACAM3, CGM1, CD66D, Carcinoembryonic antigen-related cell adhesion molecule 3, Carcinoembryonic antigen CGM1

---

• 

  FC experiment of human peripheral blood leukocytes using 98169-1-RR (same clone as 98169-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM3/6 (CD66c/d) Rabbit Recombinant Antibody (98169-1-RR, Clone: 241254D1) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98169-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98169-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98169-1-RR against Human CEACAM3/6 (CD66c/d) were performed. The affinity constant is 2.19 nM.

---

Geprüfte Anwendungen

Produktinformation

98169-1-PBS bindet in FC CEACAM3/6 (CD66c/d) und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: carcinoembryonic antigen-related cell adhesion molecule 3
• Berechnetes Molekulargewicht: 252 aa, 27 kDa
• GenBank-Zugangsnummer: BC106728
• Gene symbol: CEACAM3
• Gene ID (NCBI): 1084
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily of cell adhesion molecules. CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in controlling cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). CEACAM3, also named as CD66d and CGM1, is exclusively expressed on granulocytes and acts as the major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms (PMID: 18606569). CEACAM6, also known as CD66c, is normally expressed on the surface of myeloid and epithelial surfaces and upregulated preferentially at the apical/luminal membranes of many tumors (PMID: 27595061; 35082925). This antibody is raised against 35-155 aa of human CEACAM3/CD66d and can cross-react with CEACAM6/CD66c.