CFHR3 Polyklonaler Antikörper

CFHR3 Polyklonal Antikörper für WB, IHC, IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16583-1-PBS

Synonyme

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  WB analysis using 16583-1-AP (same clone as 16583-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16583-1-AP (CFHR3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16583-1-PBS in a different storage buffer formulation.

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  WB analysis of human heart using 16583-1-AP (same clone as 16583-1-PBS)

  human heart tissue were subjected to SDS PAGE followed by western blot with 16583-1-AP (CFHR3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16583-1-PBS in a different storage buffer formulation.

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  IP experiment of HepG2 using 16583-1-AP (same clone as 16583-1-PBS)

  IP result of anti-CFHR3 (IP:16583-1-AP, 4ug; Detection:16583-1-AP 1:300) with HepG2 cells lysate 2400ug. This data was developed using the same antibody clone with 16583-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 16583-1-AP (same clone as 16583-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 16583-1-AP (CFHR3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16583-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 16583-1-AP (same clone as 16583-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 16583-1-AP (CFHR3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16583-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

16583-1-PBS bindet in WB, IHC, IP, Indirect ELISA CFHR3 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CFHR3 fusion protein Ag9963
• Vollständiger Name: complement factor H-related 3
• Berechnetes Molekulargewicht: 330 aa, 37 kDa
• Beobachtetes Molekulargewicht: 45-56 kDa
• GenBank-Zugangsnummer: BC058009
• Gene symbol: CFHR3
• Gene ID (NCBI): 10878
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CFHR3, also named as DOWN16, belongs to the complement factor H-related protein family. Expressed by the liver and secreted in plasma, human CFHR3 is composed of five short consensus repeats (SCRs), and it also has a 19-amino acid signal peptide and four N-linked glycosylation sites. It may be involved in complement regulation. Deletion of CFHR1 and CFHR3 genes was found to be associated with decreased risk of age-related macular degeneration (AMD), and with an increased risk of atypical hemolytic-uremic syndrome (aHUS).