hCG Beta Polyklonaler Antikörper

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• KD/KO Validated

hCG Beta Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen(15)

Kat-Nr. : 11615-1-AP

Synonyme

CGB, CGB,hCG, CG beta, CGB3, CGbeta

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  IHC staining of human placenta using 11615-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 11615-1-AP (hCG beta antibody at dilution of 1:200 (under 10x lens).

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  IHC staining of human placenta using 11615-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 11615-1-AP (hCG beta antibody at dilution of 1:200 (under 40x lens).

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  IHC staining of human placenta using 11615-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 11615-1-AP (hCG beta antibody at dilution of 1:200 (under 10x lens).

• 

  IHC staining of human placenta using 11615-1-AP

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 11615-1-AP (hCG beta antibody at dilution of 1:200 (under 40x lens).

• 

  IHC staining of human breast cancer using 11615-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11615-1-AP (hCG beta antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

• 

  IHC staining of human breast cancer using 11615-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11615-1-AP (hCG beta antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Plazenta-Gewebe, humanes Mammakarzinomgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 11 publications below
• IHC: See 2 publications below
• IF: See 4 publications below

Produktinformation

11615-1-AP bindet in WB, IHC, IF, ELISA hCG Beta und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: hCG Beta fusion protein Ag2191
• Vollständiger Name: CG beta
• Berechnetes Molekulargewicht: 165 aa, 18 kDa
• GenBank-Zugangsnummer: BC022796
• Gene symbol: hCG Beta
• Gene ID (NCBI): 1082
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Beta-hCG (beta-human chorionic gonadotropin) is a glycoprotein hormone produced by the placenta during pregnancy. It is a critical marker used in both obstetrics and oncology for various diagnostic and monitoring purposes. hCG is composed of two subunits: an alpha subunit (similar to other glycoprotein hormones like LH, FSH, and TSH) and a unique beta subunit (β-hCG). The beta subunit is the primary focus for diagnostic tests due to its specificity. β-hCG is initially secreted by the syncytiotrophoblast cells surrounding the developing embryo and later by the placenta.

Publikationen

Species	Application	Title
human	WB	J Transl Med; STK40 inhibits trophoblast fusion by mediating COP1 ubiquitination to degrade P57Kip2; Authors - Xia Li
human	WB,IHC	iScience; Demethylase FTO-mediated m6A modification of SIK1 modulates placental cytotrophoblast syncytialization in type 2 diabetes mellitus; Authors - Jie Ning
human	IF	EBioMedicine; Molecular mechanisms underlying altered neurobehavioural development of female offspring of mothers with polycystic ovary syndrome: FOS-mediated regulation of neurotrophins in placenta.; Authors - Fangfang Wang
human	IF	Cell Signal; Hypermethylation and low expression of FOXM1 predisposes women to unexplained recurrent miscarriage by impairing trophoblast stem cell proliferation; Authors - Youqing Jiang
human	WB	Mol Cell Endocrinol; Activation of G protein-coupled estrogen receptor stimulates placental human chorionic gonadotropin expression through PKA-CREB signaling; Authors - Sizhu Yang
human	WB	Biomolecules; Calnexin Is Involved in Forskolin-Induced Syncytialization in Cytotrophoblast Model BeWo Cells; Authors - Hitomi Matsukawa