CHRNG Polyklonaler Antikörper

CHRNG Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21928-1-PBS

Synonyme

ACHRG, Acetylcholine receptor subunit gamma

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  WB analysis using 21928-1-AP (same clone as 21928-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 21928-1-AP (CHRNG antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21928-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 21928-1-AP (same clone as 21928-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 21928-1-AP (CHRNG antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21928-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

21928-1-PBS bindet in WB, Indirect ELISA CHRNG und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CHRNG fusion protein Ag16505
• Vollständiger Name: cholinergic receptor, nicotinic, gamma
• Berechnetes Molekulargewicht: 465 aa, 52 kDa
• Beobachtetes Molekulargewicht: 58 kDa
• GenBank-Zugangsnummer: BC111802
• Gene symbol: CHRNG
• Gene ID (NCBI): 1146
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Acetylcholine receptor subunit gamma is a protein that in humans is encoded by the CHRNG gene. The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.