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CLASP1 Polyklonaler Antikörper

CLASP1 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13713-1-AP

Synonyme

CLASP1, CLIP associating protein 1, hOrbit1, KIAA0622, MAST1, Multiple asters homolog 1, Protein Orbit homolog 1

Galerie der Validierungsdaten

Geprüfte Anwendungen

Produktinformation

13713-1-AP bindet in ELISA CLASP1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CLASP1 fusion protein Ag4651
Vollständiger Name cytoplasmic linker associated protein 1
Berechnetes Molekulargewicht 1538 aa, 169 kDa
GenBank-ZugangsnummerBC032563
Gene symbol CLASP1
Gene ID (NCBI) 23332
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CLASP1 and CLASP2 are homologous mammalian proteins, which associate with the ends of growing microtubules. In interphase cells CLASPs can attach microtubule plus ends to the cortex and stabilize them by repeatedly rescuing them from depolymerization. A truncated form of CLASP1 lacking the kinetochore binding domain behaves as a dominant negative, leading to the formation of radial arrays of microtubule bundles that are highly resistant to depolymerization. Microinjection of CLASP1-specific antibodies suppresses microtubule dynamics at kinetochores and throughout the spindle, resulting in the formation of monopolar asters with chromosomes buried in the interior. Therefore, CLASP1 is required at kinetochores for attached microtubules to exhibit normal dynamic behavior.