• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

CLCC1 Monoklonaler Antikörper

CLCC1 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

3C4B4

Kat-Nr. : 68853-7-PBS

Synonyme

Mid-1-related chloride channel protein 1, MCLC, KIAA0761, Chloride channel CLIC-like protein 1, chloride channel CLIC like 1

Filter:
  • Western Blot (WB) analysis of hTERT-RPE1 cells using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis of hTERT-RPE1 using 68853-7-Ig (same clone as 68853-7-PBS)

    hTERT-RPE1 cells were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of COLO 320 cells using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis of COLO 320 using 68853-7-Ig (same clone as 68853-7-PBS)

    COLO 320 cells were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis using 68853-7-Ig (same clone as 68853-7-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis using 68853-7-Ig (same clone as 68853-7-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68853-7-PBS bindet in WB, Indirect ELISA CLCC1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen CLCC1 fusion protein Ag24682
Vollständiger Name chloride channel CLIC-like 1
Berechnetes Molekulargewicht 551 aa, 62 kDa
Beobachtetes Molekulargewicht 50-60 kDa
GenBank-ZugangsnummerBC002939
Gene symbol CLCC1
Gene ID (NCBI) 23155
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CLCC1, also known as MCLC, is a transmembrane protein that localizes to intracellular compartments, including endoplasmic reticulum (ER), and it functions as a chloride channel (PMID: 11279057). It has been shown that loss of CLCC1 results in ER Stress, misfolded protein accumulation, and neurodegeneration (PMID: 25698737). CLCC1 forms homomultimer in the ER membrane and is a pore-forming component of an anion channel. Studies found that disruption of ER ion homeostasis maintained by CLCC1 is one of the causes of neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) (PMID: 37142673).