CLEC10A/CD301 Rekombinanter Antikörper

CLEC10A/CD301 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241857C11

Kat-Nr. : 98245-1-PBS

Synonyme

CLEC10A, C-type lectin domain family 10 member A, CLECSF14, CLECSF13, CD301

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  FC experiment of Human immature monocyte-derived dendritic cells using 98245-1-RR (same clone as 98245-1-PBS)

  1x10^6 Human immature monocyte-derived dendritic cells were surface stained with 0.25 ug Anti-Human CLEC10A/CD301 Rabbit Recombinant Antibody (98245-1-RR, Clone: 241857C11) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98245-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98245-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98245-1-RR against Human CLEC10A/CD301 were performed. The affinity constant is below 1 pM.

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Geprüfte Anwendungen

Produktinformation

98245-1-PBS bindet in FC CLEC10A/CD301 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: C-type lectin domain family 10, member A
• Berechnetes Molekulargewicht: 316 aa, 35 kDa
• GenBank-Zugangsnummer: BC039011
• Gene symbol: CLEC10A
• Gene ID (NCBI): 10462
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

C-type lectin domain family 10 member A (CLEC10A), also known as CD301, macrophage galactose-type C-type lectin (MGL), DC-asialoglyco protein receptor (DC-ASGP-R) or human macrophage lectin (HML), is a type II transmembrane glycoprotein having a calcium-dependent carbohydrate recognition domain (PMID: 8598452; 11919201; 11698450). CLEC10A is expressed exclusively by myeloid professional antigen-presenting cells such as immature dendritic cells (DCs) and alternatively activated macrophages (PMID: 16998493). CLEC10A is a marker for human CD1c+ DCs (cDC2) (PMID: 29755453). It functions as an endocytic receptor for glycosylated antigens (PMID: 11919201).