CLEC10A/CD301 Rekombinanter Antikörper

CLEC10A/CD301 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241857C11

Kat-Nr. : 98245-1-RR

Synonyme

CLEC10A, C-type lectin domain family 10 member A, CLECSF14, CLECSF13, CD301

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  FC experiment of Human immature monocyte-derived dendritic cells using 98245-1-RR

  1x10^6 Human immature monocyte-derived dendritic cells were surface stained with 0.25 ug Anti-Human CLEC10A/CD301 Rabbit Recombinant Antibody (98245-1-RR, Clone: 241857C11) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98245-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98245-1-RR against Human CLEC10A/CD301 were performed. The affinity constant is below 1 pM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Human immature monocyte-derived dendritic cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98245-1-RR bindet in FC CLEC10A/CD301 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: C-type lectin domain family 10, member A
• Berechnetes Molekulargewicht: 316 aa, 35 kDa
• GenBank-Zugangsnummer: BC039011
• Gene symbol: CLEC10A
• Gene ID (NCBI): 10462
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

C-type lectin domain family 10 member A (CLEC10A), also known as CD301, macrophage galactose-type C-type lectin (MGL), DC-asialoglyco protein receptor (DC-ASGP-R) or human macrophage lectin (HML), is a type II transmembrane glycoprotein having a calcium-dependent carbohydrate recognition domain (PMID: 8598452; 11919201; 11698450). CLEC10A is expressed exclusively by myeloid professional antigen-presenting cells such as immature dendritic cells (DCs) and alternatively activated macrophages (PMID: 16998493). CLEC10A is a marker for human CD1c+ DCs (cDC2) (PMID: 29755453). It functions as an endocytic receptor for glycosylated antigens (PMID: 11919201).