CLEC12A/CD371 Rekombinanter Antikörper

CLEC12A/CD371 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242620B12

Kat-Nr. : 98357-1-RR

Synonyme

CD371, Clec12a, CLL-1, C-type lectin domain family 12 member A, C-type lectin-like molecule 1

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  FC experiment of mouse splenocytes using 98357-1-RR

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CLEC12A/CD371 Rabbit RecAb (98357-1-RR, Clone: 242620B12) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 405 Anti-Mouse CD11c (N418) Mouse IgG2a Recombinant Antibody (CL405-65602, Clone: N418) and APC Anti-Mouse CD8a (53-6.7) (APC-65069, Clone: 53-6.7). CD8+ cells were gated. Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Splenozyten

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98357-1-RR bindet in FC CLEC12A/CD371 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CLEC12A/CD371 fusion protein Eg2726
• Vollständiger Name: C-type lectin domain family 12, member a
• Berechnetes Molekulargewicht: 31 kDa
• GenBank-Zugangsnummer: /
• Gene symbol: Clec12a
• Gene ID (NCBI): 232413
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

CLEC12A, also known as CD371, MICL, DCAL-2 or CLL-1, is a type II transmembrane glycoprotein and a member of the C-type lectin superfamily (PMID: 30401586). This protein, which contains a single C-type lectin-like domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), is related to LOX-1 and Dectin-1 and is variably spliced and highly N-glycosylated (PMID: 14739280). Its ITIM sequence recruits the tyrosine phosphatases SHP-1 and SHP-2 to negatively regulate Syk signaling.