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CLIC2 Polyklonaler Antikörper

CLIC2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 14935-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using CLIC2 Polyclonal antibody (14935-1-AP)

    WB analysis using 14935-1-AP (same clone as 14935-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14935-1-AP (CLIC2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14935-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

14935-1-PBS bindet in WB, Indirect ELISA CLIC2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CLIC2 fusion protein Ag6766
Vollständiger Name chloride intracellular channel 2
Berechnetes Molekulargewicht 28 kDa
Beobachtetes Molekulargewicht28-30 kDa
GenBank-ZugangsnummerBC005367
Gene symbol CLIC2
Gene ID (NCBI) 1193
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CLIC2 (chloride intracellular channel 2), also known as CLCNL2. It is expected to be located in cytoplasm and membrane. CLIC-2 exists as a monomer. It also has an unusual enzyme activity profile. While the CXXC active site motif is conserved between CLIC-2 and the glutaredoxins, no thiol transferase activity was detected. In contrast, low glutathione peroxidase activity was recorded. CLIC-2 was found to be widely distributed in tissues including heart and skeletal muscle. Functional studies showed that CLIC-2 inhibited cardiac ryanodine receptor Ca2+ release channels in lipid bilayers when added to the cytoplasmic side of the channels and inhibited Ca2+ release from cardiac sarcoplasmic reticulum vesicles. The calculated molecular weight of CLIC2 is 28 kDa.