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CLUH Rekombinanter Antikörper

CLUH Rekombinant Antikörper für IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241640C11

Kat-Nr. : 84321-4-PBS

Synonyme

KIAA0664, Protein KIAA0664, FLJ23672, CLU1, 241640C11

Filter:
  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using CLUH Recombinant antibody (84321-4-RR)

    IF Staining of HeLa using 84321-4-RR (same clone as 84321-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CLUH antibody (84321-4-RR, Clone: 241640C11 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84321-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84321-4-RR

    Affinity and Kinetic Characterization of 84321-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84321-4-RR against Human CLUH were performed. The affinity constant is 7.19 nM.

Geprüfte Anwendungen

Produktinformation

84321-4-PBS bindet in IF/ICC, Indirect ELISA CLUH und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen CLUH fusion protein Ag34275
Vollständiger Name KIAA0664
GenBank-ZugangsnummerBC156940
Gene symbol CLUH
Gene ID (NCBI) 23277
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Clustered mitochondria homolog (CLUH) is a conserved RNA-binding protein, that binds transcripts encoding proteins involved in the respiratory chain, the tricarboxylic acid (TCA) cycle, and other mitochondrial metabolic pathways. Upon loss of CLUH, target mRNAs are subjected to faster decay, and their respective proteins are decreased in abundance. This leads to alterations in mitochondrial distribution (mitochondrial clustering as the gene name alludes to) mitochondrial cristae integrity, respiratory defects, loss of mtDNA, and decreased activity of TCA cycle enzymes. (PMID: 35559794)