CMTM8 Polyklonaler Antikörper

CMTM8 Polyklonal Antikörper für WB, IHC, IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 15039-1-PBS

Synonyme

Chemokine-like factor superfamily member 8, CKLF-like MARVEL transmembrane domain-containing protein 8, CKLFSF8

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  WB analysis of mouse bladder using 15039-1-AP (same clone as 15039-1-PBS)

  mouse bladder tissue were subjected to SDS PAGE followed by western blot with 15039-1-AP (CMTM8 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

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  IP experiment of mouse liver using 15039-1-AP (same clone as 15039-1-PBS)

  IP result of anti-CMTM8 (IP:15039-1-AP, 4ug; Detection:15039-1-AP 1:300) with mouse liver tissue lysate 6800ug. This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

15039-1-PBS bindet in WB, IHC, IP, Indirect ELISA CMTM8 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CMTM8 fusion protein Ag6776
• Vollständiger Name: CKLF-like MARVEL transmembrane domain containing 8
• Berechnetes Molekulargewicht: 20 kDa
• Beobachtetes Molekulargewicht: 25-28 kDa
• GenBank-Zugangsnummer: BC041390
• Gene symbol: CMTM8
• Gene ID (NCBI): 152189
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CMTM8, also known as CKLFSF8, is a member of the chemokine-like factor superfamily (CKLFSF). Proteins of this family share similarity with both the chemokine and the transmembrane 4 superfamilies. CMTM8 is an attenuator of EGF-induced signaling (PMID: 16263120). Overexpression of CMTM8 accelerates ligand-induced clearance of EGFR from the cell surface and induces apoptosis via caspase-dependent and -independent pathways (PMID: 17149703). An alternative splice form of CMTM8, CMTM8-v2, arises from a deletion of exon 2. CMTM8-v2 maintains the ability to induce apoptosis (PMID: 17681841).