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CNKSR2 Polyklonaler Antikörper

CNKSR2 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 24054-1-PBS

Synonyme

CNK homolog protein 2, CNK2, Connector enhancer of KSR 2, KIAA0902, KSR2

Filter:
  • Western Blot (WB) analysis of various lysates using CNKSR2 Polyclonal antibody (24054-1-AP)

    WB analysis using 24054-1-AP (same clone as 24054-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24054-1-AP (CNKSR2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24054-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat liver tissue using CNKSR2 Polyclonal antibody (24054-1-AP)

    IHC staining of rat liver using 24054-1-AP (same clone as 24054-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 24054-1-AP (CNKSR2 antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24054-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

24054-1-PBS bindet in WB, IHC, Indirect ELISA CNKSR2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CNKSR2 fusion protein Ag21183
Vollständiger Name connector enhancer of kinase suppressor of Ras 2
Berechnetes Molekulargewicht 1034 aa, 118 kDa
Beobachtetes Molekulargewicht 110 kDa, 130 kDa
GenBank-ZugangsnummerBC126121
Gene symbol CNKSR2
Gene ID (NCBI) 22866
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-affinitätsgereinigt
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The Connector Enhancer of Kinase Suppressor of Ras-2 (CNKSR2), also known as CNK2 or MAGUIN, KIAA0902 and KSR2, is a scaffolding molecule that contains functional protein binding domains (PMID: 35053419). CNKSR2 interacts with different molecules, including RAF1, ARHGAP39, and CYTH2, and regulates the Mitogen-Activated Protein Kinase (MAPK) cascade and small GTPase signaling (PMID: 35053419). The study identify a molecular complex comprising CNKSR2 and the guanine nucleotide exchange factor (GEF) for ARF small GTPases, CYTH2, that is necessary for the proper development of granule neurons in the mouse hippocampus (PMID: 34800437). CNKSR2 plays a key role in regulating cell proliferation, and differentiation through multiple receptor tyrosine kinase pathways (PMID: 35053419). The molecular weight of CNKSR2 is mainly 117 kDa (PMID: 29534682). It has also been reported that CNKSR2 immunoblotted signal of about 110 kDa was detected, while a 130 kDa signal was detected (PMID: 34800437).