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CNOT3 Monoklonaler Antikörper

CNOT3 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

Hausschwein, human, Kaninchen, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2E12C6

Kat-Nr. : 68436-1-PBS

Synonyme

CCR4 associated factor 3, CNOT3, KIAA0691, LENG2, NOT3, NOT3H

Filter:
  • Western Blot (WB) analysis of various lysates using CNOT3 Monoclonal antibody (68436-1-Ig)

    WB analysis using 68436-1-Ig (same clone as 68436-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68436-1-Ig (CNOT3 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68436-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68436-1-PBS bindet in WB, Indirect ELISA CNOT3 und zeigt Reaktivität mit Hausschwein, human, Kaninchen, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Kaninchen, Maus, Ratte
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen CNOT3 fusion protein Ag33646
Vollständiger Name CCR4-NOT transcription complex, subunit 3
Berechnetes Molekulargewicht 120 kDa
Beobachtetes Molekulargewicht120 kDa
GenBank-ZugangsnummerBC016474
Gene symbol CNOT3
Gene ID (NCBI) 4849
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The CCR4-NOT complex, the major deadenylase in mammalian cells, shortens the mRNA poly(A) tail and leads to the destabilization of mRNAs. The CCR4-NOT complex plays pivotal roles in various physiological functions, including cell apoptosis, proliferation, and metabolism [PMID:22342980]. CNOT3, belongs to the CCR4-NOT complex, has a critical role in maintaining mouse and human ESC identity as a protein complex and inhibit differentiation into the extraembryonic lineages. It is also involved in the regulation of the spindle assembly checkpoint [PMID:22342980,22367759].