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CNOT6 Polyklonaler Antikörper

CNOT6 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 17935-1-PBS

Synonyme

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  • Western Blot (WB) analysis of Jurkat cells using CNOT6 Polyclonal antibody (17935-1-AP)

    WB analysis of Jurkat using 17935-1-AP (same clone as 17935-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 17935-1-AP (CNOT6 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17935-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

17935-1-PBS bindet in WB, Indirect ELISA CNOT6 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CNOT6 fusion protein Ag11506
Vollständiger Name CCR4-NOT transcription complex, subunit 6
Berechnetes Molekulargewicht557 aa, 63.3 kDa
Beobachtetes Molekulargewicht 63 kDa
GenBank-ZugangsnummerBC027476
Gene symbol CNOT6
Gene ID (NCBI) 57472
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The evolutionarily conserved CCR4-NOT (CNOT) complex regulates mRNA metabolism in eukaryotic cells. This regulation occurs at different levels of mRNA synthesis and degradation, including transcription initiation, elongation, deadenylation, and degradation (PMID: 12882519). Multiple components, including CNOT1, CNOT2, CNOT3, CNOT4, CNOT6, CNOT6L, CNOT7, CNOT8, CNOT9, and CNOT10 have been identified in this complex (PMID: 19558367). In addition, the subunit composition of this complex has been shown to vary among different tissues (PMID: 21741365). The various CNOT proteins display different functions, with CNOT6, CNOT6L, CNOT7, and CNOT8 exhibiting 3'-5' RNAse activity (PMID: 11889047). Research studies indicate that the CCR4-NOT deadenylase subunits CNOT6 and CNOT6L help mediate cell survival and play a role in cell proliferation, P-body formation, and regulation of gene expression (PMID: 21233283). Additional research evidence suggests that CNOT6 can act as a nuclear hormone receptor coactivator that associates with ZNF335 (NIF-1) to regulate expression from specific RARα regulated genes (PMID: 18180299).